[{"data":1,"prerenderedAt":37},["ShallowReactive",2],{"news-2025-03-gpr75-cryoem":3},{"id":4,"title":5,"body":6,"date":25,"description":26,"extension":27,"kind":28,"link":29,"meta":30,"navigation":31,"path":32,"seo":33,"stem":34,"summary":35,"__hash__":36},"news\u002Fnews\u002F2025-03-gpr75-cryoem.md","GPR75 cryo-EM structure unlocks small-molecule discovery",{"type":7,"value":8,"toc":21},"minimark",[9,18],[10,11,12,13,17],"p",{},"Abilita's structural biology team determined the first cryo-EM structure of\nthe orphan GPCR ",[14,15,16],"strong",{},"GPR75"," in an inactive, EMP-stabilised state. GPR75 has\nbeen validated through human genetics as a target for obesity — loss-of-\nfunction mutations correlate with lower BMI — but historically defied\nstructural characterisation.",[10,19,20],{},"The structure has enabled in-silico screening of multiple small-molecule\nfamilies, with lead candidates expected in 2H 2026.",{"title":22,"searchDepth":23,"depth":23,"links":24},"",2,[],"2025-03-18","Abilita's structural biology team determined the first cryo-EM structure of\nthe orphan GPCR GPR75 in an inactive, EMP-stabilised state. GPR75 has\nbeen validated through human genetics as a target for obesity — loss-of-\nfunction mutations correlate with lower BMI — but historically defied\nstructural characterisation.","md","publication",null,{},true,"\u002Fnews\u002F2025-03-gpr75-cryoem",{"title":5,"description":26},"news\u002F2025-03-gpr75-cryoem","First reported cryo-EM structure of an EMP-stabilised GPR75 enables in silico screening of inverse-agonist scaffolds for obesity.","BVrqSapAdcQIqzZ8IfI1YGP4vm-73tqGvL1nAfDQ1AE",1779487983620]